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Emily J. Tsai, MD, FACC, FAHA

  • Assistant Professor of Medicine
Emily J. Tsai, MD, FACC, FAHA

Emily J. Tsai, MD, FACC, FAHA, is an Assistant Professor of Medicine in the Department of Medicine, Division of Cardiology. She is an attending physician in the Center for Advanced Cardiac Care at New York-Presbyterian Hospital at the Columbia University Irving Medical Center. Board-certified in Cardiovascular Medicine and Advanced Heart Failure and Transplant Cardiology, Dr. Tsai specializes in caring for heart failure patients who require, or have received, a ventricular assist device or heart transplant.

Dr. Tsai is a magna cum laude graduate in engineering sciences of Harvard College. She received her MD cum laude from Harvard Medical School in the Harvard-MIT Division of Health Sciences and Technology. She completed internal medicine residency training at the Hospital of the University of Pennsylvania and cardiology fellowship at The Johns Hopkins Hospital. While at Hopkins, Dr. Tsai focused her clinical training in advanced heart failure and transplant cardiology. Supported by a Ruth L. Kirschstein National Research Service Award, Dr. Tsai also completed post-doctoral basic cardiovascular research training at Johns Hopkins University in the laboratory of David A. Kass, MD, FAHA. After her post-doctoral fellowship, Dr. Tsai was recruited to Temple University School of Medicine as an assistant professor of medicine and physiology and a principal investigator in its Cardiovascular Research Center. In 2015, Dr. Tsai joined the faculty of Columbia University College of Physicians & Surgeons and established her laboratory in integrative cardiac pathophysiology.

Dr. Tsai is a physician-scientist who focuses on the molecular mechanisms of heart failure, specifically the dysregulation of nitric oxide signaling within heart cells and the pathobiology of right ventricular dysfunction. She gained early scientific training in diverse fields ranging from neurophysiology to virology and immunology and subsequently pursued post-graduate scientific training in molecular cardiology. Accordingly, Dr. Tsai uses multidisciplinary and integrative approaches to investigating the molecular pathophysiology of heart failure. A translational investigator, Dr. Tsai also analyzes biological samples of heart failure patients to direct mechanistic studies in in vivo animal models as well as in vitro cell culture systems. The ultimate goal of the Tsai laboratory is to discover novel approaches for the treatment of chronic heart failure, in particular medically treated chronic heart failure (Stage C) and with an emphasis on preventing and reversing right ventricular failure. The Tsai lab is also interested in gender differences in the molecular signaling of heart failure.

Dr. Tsai has received national recognition for her research accomplishments. Her research awards include the 2017 American College of Cardiology Presidential Career Development Award, the 2017 Lewis Katz Cardiovascular Research Prize, the inaugural 2016 M. Irene Ferrer Scholar Award, the 2015 Columbia University Provost's Grant for Junior Faculty Who Contribute to the Diversity Goals of the University, and the 2012 Jay N. Cohn New Investigator Award in Basic Science from the Heart Failure Society of America. Dr. Tsai has received numerous research grants including an NHLBI R01, an NHLBI K08 Career Development Award, an NHLBI R03, and the AHA National Scientist Development Grant.

Dr. Tsai reviews grants for the American Heart Association and is an author of the 2013 ACCF/AHA Guideline for the Management of Heart Failure.

Languages Spoken

  • Mandarin

Education & Training

  • MD, Harvard Medical School
  • Internship: Hospital of the University of Pennsylvania
  • Residency: Hospital of the University of Pennsylvania
  • Fellowship: Johns Hopkins Hospital

Centers / Institutes / Programs

Lab Locations

  • William Black Building

    650 West 168th Street
    8-510
    New York, NY 10032

Committees / Societies / Memberships

American College of Cardiology, Fellow

American Heart Association, Fellow

Basic Cardiovascular Science Council, American Heart Association

Council of Functional Genomics and Translational Biology, American Heart Association

Heart Failure Society of America

International Society of Heart Research

American Physiological Society

Honors & Awards

1992          Robert C. Byrd Scholarship
1992          Presidential Scholar Finalist
1996          Thomas T. Hoopes Prize, Harvard College
1996          Magna Cum Laude, Harvard College
1999          Inductee, The Aesculapian Club, Harvard Medical School
1999          Howard Hughes Medical Institute-National Institutes of Health Research Scholar
2000          Howard Hughes Medical Institute-National Institutes of Health Advanced Scholar
2001          Howard Hughes Medical Institute Continued Fellowship for Medical Studies

2001          Wellsford & Mildred Clark Medical Memorial Scholarship
2002          Cum Laude, Harvard Medical School
2007          Ruth L. Kirschstein National Research Service Award
2008          Finalist, Northwestern Cardiovascular Young Investigators’ Forum
2010          Faculty Development Research Award, Department of Medicine, Temple University
2012          Jay N. Cohn New Investigator Award in Basic Science, Heart Failure Society of America

2015          Provost's Grant for Junior Faculty Who Contribute to the Diversity Goals of the University, Columbia University
2016          M. Irene Ferrer Scholar Award, Columbia University College of P&S Department of Medicine and The Foundation for Gender-Specific Medicine

2017          Presidential Career Development Award, American College of Cardiology

2018          Lewis Katz Cardiovascular Research Prize 

NIH Grants

  • NOVEL CARDIOPROTECTIVE SGC/CGMP MICRODOMAINS: THERAPEUTIC TARGETS IN MEDICALLY TREATED HF (Federal Gov)

    Jul 1 2017 - Jun 30 2022

    THERAPEUTIC POTENTIAL OF MYOCARDIAL SOLUBLE GUANYLYL CYCLASE SIGNALING IN RIGHT VENTRICULAR DYSFUNCTION (Federal Gov)

    Aug 15 2016 - Jul 31 2018

    THERAPEUTIC POTENTIAL OF MYOCARDIAL SOLUBLE GUANYLYL CYCLASE STIMULATION IN RIGHT VENTRICULAR DYSFUNCTION: MICRODOMAINS OF NOVEL CARDIOPROTECTIVE CGMP SIGNALING MECHANISMS (Private)

    Jul 1 2017 - Jun 30 2018

    FUNCTIONAL IMPLICATIONS OF CAVEOLAE LOCALIZED MYOCARDIAL SGC IN HEART FAILURE (Federal Gov)

    Aug 10 2012 - Jul 31 2017