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Hiroo Takayama, MD, PhD

  • Associate Professor of Surgery at CUMC
  • Director of Cardiovascular Institute
  • Co-Director, Aortic Program
  • Co-Director, Marfan Clinic
  • Co-Director, HCM program, Division of Cardiac, Vascular & Thoracic Surgery
Hiroo Takayama, MD, PhD

Dr. Hiroo Takayama has more than 20 years of experience in treating patients with heart and vascular problems. As the Director of the Aortic Surgery Program and co-Director of the Aortic Center, the Hypertrophic Cardiomyopathy Center, and the Marfan Clinic at New York Presbyterian/Columbia, Dr. Takayama has contributed to the care of over 2,000 patients (as of 2017) by performing a variety of aortic and cardiac surgical procedures, approximately 300-350 operations every year.

Dr. Takayama is internationally recognized for his work on complex aortic surgery (minimally invasive aortic surgery, valve-sparing aortic root replacement, aortic valve repair, aortic arch and thoracoabdominal aneurysm repair), hybrid aortic surgery (thoracic endovascular aneurysm repair), myectomy for obstructive hypertrophic cardiomyopathy, and heart failure surgery.

He is a leader in outcome research in aortic diseases and heart failure. He has published more than 150 manuscripts in prestigious, peer-reviewed journals and has authored numerous book chapters about heart disease.

Dr. Takayama attended University of Tokyo for Medical School, did his internship at University of Tokyo, general surgery residency in University of Washington Medical Center, and cardio-thoracic surgery fellowship in New-York Presbyterian/Columbia University Medical Center.

Languages Spoken

  • Japanese

Education & Training

  • University of Tokyo (Japan)
  • Internship: University of Tokyo Hospital
  • Residency: University of Tokyo Hospital
  • Residency: NewYork-Presbyterian Hospital/Columbia University Medical Center
  • Residency: University of Washington Medical Center
  • Fellowship: University of Washington Medical Center

Presentations

  1. Xydas S, Wei B, Takayama H, Russo MJ, Smith CR, Bacchetta MD, Stewart AS. Use of Subclavian-Carotid Bypass and Thoracic Stent Grafting to Minimize Cerebral Ischemia in Total Aortic Arch Reconstructions. The 89th Annual Meeting of the American Association for Thoracic Surgery. May 13, 2009
  2. Takayama H, Naka Y, Argenziano M, Oz MC, Stewart AS, Williams MR, Smith CR. Quantitative Assessment of Technical Proficiency of Residents in Cardiac Surgery. The 89th Annual Meeting of the American Association for Thoracic Surgery. May 10, 2009
  3. Takayama H. The role of PA and NP in cardiac surgery in US: report from Columbia University Medical Center. The 56th Annual Scientific Session of the Japanese College of Cardiology Sep 8, 2008
  4. Takayama H. Transnational Training: from Japan to US. 2008 Annual Scientific Meeting of The International Society for Minimally Invasive Cardiothoracic Surgery. June 12, 2008.
  5. Takayama H. Cardiac Surgery Training System in Japan. 2008 Annual Scientific Meeting of The International Society for Minimally Invasive Cardiothoracic Surgery. June 12, 2008.
  6. Tabata M, Takayama H, Smith CR, Stewart AS. Modified Bentall Operation with Bioprosthetic Valved Conduit: Columbia University Experience. Aortic Symposium 2008. May 7, 9, 2008.
  7. Takayama H, Bowdish ME, Smith CR, Stewart AS. Importance of Aortic Surgery Specialty in Aortic Root Surgery. Aortic Symposium 2008. May 7, 9, 2008.
  8. Davies RR, Takayama H, Stewart AS. Teaching Valve-Sparing Aortic Root Replacements- Successful Outcomes within a Training Program. 18th World Congress- World Society of Cardio-Thoracic Surgeons. April 30, 2008.
  9. Davies RR, Takayama H, Stewart AS. Routine Use of Antegrade Cerebral Perfusion without Deep Hypothermia for Operations on the Aortic Root. 18th World Congress- World Society of Cardio-Thoracic Surgeons. April 30, 2008.

Committees / Societies / Memberships

  • American College of Surgeons
  • Japanese Surgical Society
  • Japanese Association for Thoracic Surgery
  • Japanese Society of Gastroenterological Surgery
  • Japanese Society of Pediatric Cardiology & Cardiac Surgery
  • Japanese Society for Cardiovascular Surgery
  • Society of Thoracic Surgeons

Honors & Awards

  • 2016 New York Magazine's Top Doctors
  • 2012 Winner of Thoracic Surgery Residents Association Dwight C. McGoon Award

Research Interests

  • Heart failure
  • Cardiogenic shock
  • Minimally invasive aortic surgery
  • Brain protection in aortic arch surgery
  • Aortic valve repair

NIH Grants

  • SORIN UNIVERSAL REGISTRY ON AORTIC VALVE REPLACEMENT (P&S Industry Clinical Trial)

    Mar 6 2018 - Mar 6 2023

    EVALUATION OF THE THORAFLEX? HYBRID DEVICE FOR USE IN THE REPAIR OR REPLACEMENT OF THE ASCENDING AORTA, AORTIC ARCH AND DESCENDING AORTA IN AN OPEN SURGICAL PROCEDURE. (P&S Industry Clinical Trial)

    Apr 12 2017 - Apr 12 2022

    MULTICENTER EXPERIENCE WITH THE RAPID DEPLOYMENT EDWARDS INTUITY VALVE SYSTEMS FOR AORTIC VALVE REPLACEMENT (TRANSFORM TRIAL) (P&S Industry Clinical Trial)

    Dec 23 2014 - Dec 23 2019

    DEVELOPMENT OF A NOVEL IMAGEGUIDED BLOOD FLOW AND HEMODYNAMIC ASSESSMENT OF AORTIC VALVE AND ROOT UNDER CONTINUOUS-FLOW LEFT VENTRICULAR ASSIST DEVICE SUPPORT (Private)

    Jul 1 2017 - Jun 30 2019

    CENTRIMAG RVAS POST-APPROVAL STUDY (P&S Industry Clinical Trial)

    Nov 30 2012 - Nov 30 2017

Publications

  1. Ota T, Takayama H, Khalpey Z, Naka Y. Reinforcement of HeartMate II bend relief connection: champagne bottle technique. Ann Thorac Surg. 2013 Apr;95(4):e107-8.
  2. Nishimura T, Ota T, Takayama H, Naka Y. Subcostal to rib-cross incision for HeartMate II explantation: a case report. J Thorac Cardiovasc Surg. 2013 Jan;145(1):e16-7.
  3. Akashi H, Kato TS, Takayama H, Naka Y, Farr M, Mancini D, Schulze PC. Outcome of patients with cardiac sarcoidosis undergoing cardiac transplantation-Single-center retrospective analysis. J Cardiol. 2012 Nov;60(5):407-10.
  4. Javidfar J, Brodie D, Costa J, Miller J, Jurrado J, Lavelle M, Newmark A, Takayama H, Sonett JR, Bacchetta M. Subclavian artery cannulation for venoarterial extracorporeal membrane oxygenation. ASAIO J. 2012 Sep-Oct;58(5):494-8.
  5. Takayama H, Chen JM, Jorde UP, Naka Y. Implantation technique of the CentriMag biventricular assist device allowing ambulatory rehabilitation. Interact Cardiovasc Thorac Surg. 2011 Feb;12(2):110-1.
  6. Kitada S, Kato TS, Thomas SS, Conwell SD, Russo C, Ditullio M, Farr M, Christian Schulze P, Uriel N, Jorde UP, Takayama H, Naka Y, Homma S, Mancini DM. Pre-operative Echocardiographic Features Associated With Persistent Mitral Regurgitation After Left Ventricular Assist Device Implantation. J Heart Lung Transplant. 2013 Jul 11. [Epub ahead of print]
  7. Lanier GM, Orlanes K, Hayashi Y, Murphy J, Flannery M, Te-Frey R, Uriel N, Yuzefpolskaya M, Mancini DM, Naka Y, Takayama H, Jorde UP, Demmer RT, Colombo PC. Validity and Reliability of a Novel Slow Cuff-deflation System for Non-invasive Blood Pressure Monitoring in Patients with Continuous-Flow Left Ventricular Assist Device. Circ Heart Fail. 2013 Jun 27. [Epub ahead of print]
  8. Lee R, Enter D, Lou X, Feins RH, Hicks GL, Gasparri M, Takayama H, Young JN, Calhoon JH, Crawford FA, Mokadam NA, Fann JI. The Joint Council on Thoracic Surgery Education coronary artery assessment tool has high interrater reliability. Ann Thorac Surg. 2013 Jun;95(6):2064-9; discussion 2069-70.
  9. Kato TS, Cheema FH, Yang J, Kawano Y, Takayama H, Naka Y, Farr M, Lederer DJ, Baldwin MR, Jin Z, Homma S, Mancini DM, Schulze PC. Preoperative serum albumin levels predict 1-year postoperative survival of patients undergoing heart transplantation. Circ Heart Fail. 2013 Jul 1;6(4):785-91.
  10. Garan AR, Yuzefpolskaya M, Colombo PC, Morrow JP, Te-Frey R, Dano D, Takayama H, Naka Y, Garan H, Jorde UP, Uriel N. Ventricular arrhythmias and implantable cardioverter-defibrillator therapy in patients with continuous-flow left ventricular assist devices: need for primary prevention? J Am Coll Cardiol. 2013 Jun 25;61(25):2542-50.
  11. Schulze PC, Jiang J, Yang J, Cheema FH, Schaeffle K, Kato TS, Farr M, Restaino S, Deng M, Maurer M, Horn E, Latif F, Colombo PC, Jorde U, Uriel N, Haythe J, Bijou R, Drusin R, Lee SH, Takayama H, Naka Y, Mancini DM. Preoperative assessment of high-risk candidates to predict survival after heart transplantation. Circ Heart Fail. 2013 May;6(3):527-34.
  12. Uriel N, Jorde UP, Woo Pak S, Jiang J, Clerkin K, Takayama H, Naka Y, Christian Schulze P, Mancini DM. Impact of long term left ventricular assist device therapy on donor allocation in cardiac transplantation. J Heart Lung Transplant. 2013 Feb;32(2):188-95.
  13. Yuzefpolskaya M, Uriel N, Chow DS, Restaino SW, Mancini DM, Flannery M, Te-Frey R, Chichetti J, Ota T, Kim H, Dano DD, Pearson GD, Takayama H, Naka Y, Jorde UP. Prevalence and timing of bend relief disconnection in patients supported by the late version HeartMate II left ventricular assist device. J Heart Lung Transplant. 2013 Mar;32(3):320-5.
  14. Soni LK, Cedola SR, Cogan J, Jiang J, Yang J, Takayama H, Argenziano M. Right atrial lesions do not improve the efficacy of a complete left atrial lesion set in the surgical treatment of atrial fibrillation, but they do increase procedural morbidity. J Thorac Cardiovasc Surg. 2013 Feb;145(2):356-61; discussion 361-3.
  15. Takayama H, Truby L, Koekort M, Uriel N, Colombo P, Mancini DM, Jorde UP, Naka Y. Clinical outcome of mechanical circulatory support for refractory cardiogenic shock in the current era. J Heart Lung Transplant. 2013 Jan;32(1):106-11.
  16. Wu C, Kato TS, Pronschinske K, Qiu S, Naka Y, Takayama H, Schulze-Späte U, Cremers S, Shane E, Mancini D, Schulze PC. Dynamics of bone turnover markers in patients with heart failure and following haemodynamic improvement through ventricular assist device implantation. Eur J Heart Fail. 2012 Dec;14(12):1356-65.
  17. Uriel N, Morrison KA, Garan AR, Kato TS, Yuzefpolskaya M, Latif F, Restaino SW, Mancini DM, Flannery M, Takayama H, John R, Colombo PC, Naka Y, Jorde UP. Development of a Novel Echocardiography Ramp Test for Speed Optimization and Diagnosis of Device Thrombosis in Continuous-Flow Left Ventricular Assist Devices: The Columbia Ramp Study. J Am Coll Cardiol. 2012 Oct 30;60(18):1764-75.
  18. Goda A, Takayama H, Pak SW, Uriel N, Mancini D, Naka Y, Jorde UP. Aortic valve procedures at the time of ventricular assist device placement. Ann Thorac Surg. 2011 Mar;91(3):750-4.
  19. Goda A, Takayama H, Koeckert M, Pak SW, Sutton EM, Cohen S, Uriel N, Jorde U, Mancini D, Naka Y. Use of Ventricular Assist Devices in Patients with Mitral Valve Prostheses. J Card Surg. 2011 May;26(3):334-7.
  20. Munir MB, Jiang J, Mehdi MJ, Takayama H, Cheema FH. Letter to the editor: A Novel Subcutaneous Counterpulsation Device: Acute Hemodynamic Efficacy During Pharmacologically Induced Hypertension, Hypotension, and Heart Failure. Art Organs. 2011 Jan;35(1):92.
  21. Hong KN, Iribarne A, Yang J, Ramlawi B, Takayama H, Naka Y, Russo MJ. Do posttransplant outcomes differ in heart transplant recipients bridged with continuous and pulsatile flow left ventricular assist devices? Ann Thorac Surg. 2011 Jun;91(6):1899-906.
  22. Sims DB, Uriel N, González-Costello J, Deng MC, Restaino SW, Farr MA, Takayama H, Mancini DM, Naka Y, Jorde UP. Human immunodeficiency virus infection and left ventricular assist devices: A case series. J Heart Lung Transplant. 2011 Apr 22.
  23. Ben-Gal Y, Stone GW, Smith CR, Williams MR, Weisz G, Stewart AS, Takayama H, Genereux P, Argenziano M. On-pump versus off-pump surgical revascularization in patients with acute coronary syndromes: Analysis from the Acute Catheterization and Urgent Intervention Triage Strategy trial. J Thorac Cardiovasc Surg. 2011 Apr 27.
  24. Javidfar J, Brodie D, Takayama H, Mongero L, Zwischenberger J, Sonett J, Bacchetta M. Safe transport of critically ill adult patients on extracorporeal membrane oxygenation support to a regional extracorporeal membrane oxygenation center. ASAIO J. 2011 Sep-Oct;57(5):421-5.
  25. Sims DB, Takayama H, Uriel N, Gillam LD, Naka Y, Jorde UP. Ventricular assist device-associated thrombus. Circulation. 2011 Aug 16;124(7):e197-8.
  26. Kato TS, Chokshi A, Singh P, Khawaja T, Cheema F, Akashi H, Shahzad K, Iwata S, Homma S, Takayama H, Naka Y, Jorde U, Farr M, Mancini DM, Schulze PC. Effects of Continuous- Versus Pulsatile-Flow Left Ventricular Assist Devices on Myocardial Unloading and Remodeling. Circ Heart Fail. 2011 Jul 15.
  27. Takayama H, Naka Y, Kodali SK, Vincent JA, Addonizio LJ, Jorde UP, Williams MR. A novel approach to percutaneous right-ventricular mechanical support. Eur J Cardiothorac Surg. 2011 Jul 5.
  28. Hong KN, Iribarne A, Worku B, Takayama H, Gelijns AC, Naka Y, Jeevanandam V, Russo MJ. Who is the high-risk recipient? Predicting mortality after heart transplant using pretransplant donor and recipient risk factors. Ann Thorac Surg. 2011 Aug;92(2):520-7
  29. Wei B, Takayama H, Bacchetta MD. Pulmonary lobectomy in a patient with a left ventricular assist device. Ann Thorac Surg. 2009 Jun;87(6):1934-6.
  30. Takayama H, Smith CR, Bowdish ME, Stewart AS. Open Distal Anastomosis in Aortic Root Replacement using Axillary Cannulation and Moderate Hypothermia. J Thorac Cardiovasc Surg 2009 Jun; 137(6): 1450-3.
  31. Tabata M, Takayama H, Bowdish ME, Smith CR, Stewart AS. Modified Bentall operation with bioprosthetic valved conduit. Ann Thorac Surg Jun; 87(6): 1969-70.
  32. Takayama H. The role of PA and NP in cardiac surgery in US: report from Columbia University Medical Center Nippon Geka Gakkai Zasshi. 2009 Jan;110(1):52-4.
  33. Takayama H. What is Physician Assistant. Nikkei Medical. 2008 December.
  34. Takayama H, Salerno CT, Aldea GS, Verrier ED. Characteristics of Extracoronary Vascular Disease in Heart Transplant Recipient. J Card Surg. 2008 Sep-Oct;23(5):459-63.
  35. Takayama H, Soltow LO, Aldea GS. Differential Expression in Markers for Thrombin, Platelet Activation and Inflammation in Cell Saver versus Systemic Blood in Patients Undergoing On-Pump CABG. J Cardiothorac Vasc Anesth. J Cardiothorac Vasc Anesth. 2007 Aug;21(4):519-23.
  36. Takayama H, Soltow LO, Chandler WL, Vocelka CR, Aldea GS. Does the Type of Surgery Effect Systemic Response Following Cardiopulmonary Bypass? J Card Surg. 2007 Jul-Aug;22(4):307-13.
  37. Oelschlager BK, Namkung J, Takayama H. Is This Achalasia or Pseudoachanlasia? Contemporary Surgery. 2007 May; online publication.
  38. Takayama H, Nathens AB, Aldea GS, Fishbein DP, Verrier ED, Salerno CT. is pre-transplant vascular disease a risk factor for mortality and morbidity after heart transplant? Eur J Cardiothorac Surg. 2007 Mar;31(3):457-61.
  39. Cobey FC, Takayama H. Images in clinical medicine. Contraceptive failure. N Engl J Med. 2007 Jan 25;356(4):397.
  40. Takayama H, Sinanan MN, Fishbein DP, Aldea GS, Verrier ED, Salerno CT. Expectant Management is Safe for Cholelithiasis after Heart Transplant. J Heart Lung Transplant. 2006 May;25(5):539-43.
  41. Takayama H, Grinsell R, Brock D, Foy H, Pellegrini C, Horvath K. Is it Appropriate to Use Core Clerkship Grades in the Selection of Residents? Curr Surg. 2006 Nov-Dec;63(6):391-6.
  42. Takayama H, Leone RJ, Aldea GS, Fishbein DP, Verrier ED, Salerno CT. Delayed Sternal Closure after Heart Transplantation. Tex Heart Inst J. 2006;33(3):306-9.
  43. Shimamoto A, Chong AJ, Yada M, Shomura S, Takayama H, Fleisig AJ, Agnew ML, Hampton CR, Rothnie CL, Spring DJ, Pohlman TH, Shimpo H, Verrier ED. Inhibition of Toll-like receptor 4 with eritoran attenuates myocardial ischemia-reperfusion injury. Circulation. 2006 Jul 4;114(1 Suppl):I270-4.
  44. Takayama H, Aldea GS, Verrier ED, Salerno CT, Levy WC, Fishbein DP. Successful management of asystole with an isolated left ventricular assist device. J Heart Lung Transplant. 2006 Apr;25(4):490-2.
  45. Kitahori K, Takamoto S, Takayama H, Suematsu Y, Ono M, Motomura N, Morota T, Takeuchi K. A novel protocol of retrograde cerebral perfusion with intermittent pressure augmentation for brain protection. J Thorac Cardiovasc Surg. 2005 Aug;130(2):363-70.
  46. Takayama H, Chikada M, Takamoto S, Sekiguchi A, Ishizawa A. Pulmonary artery banding still has an important role in the treatmant of congenital heart disease: reply. Ann Thorac Surg. 2005 Apr;79(4):1463-4.
  47. Yada M, Shimamoto A, Hampton CR, Chong AJ, Takayama H, Rothnie CL, Spring DJ, Shimpo H, Yada I, Pohlman TH, Verrier ED. FR167653 diminishes infarct size in a murine model of myocardial ischemia-reperfusion injury. J Thorac Cardiovasc Surg. 2004 Oct;128(4):588-94.
  48. Chong AJ, Shimamoto A, Hampton CR, Takayama H, Spring DJ, Rothnie CL, Yada M, Pohlman TH, Verrier ED. Toll-like receptor 4 mediates ischemia/reperfusion injury of the heart. J Thorac Cardiovasc Surg. 2004 Aug;128(2):170-9.
  49. Takayama H, Otsuka T, Kubota H, Shibata K, Kitamura T, Takamoto S. Pseudoaneurysm developed after aortic root homograft implantation. Jpn J Thorac Cardiovasc Surg. 2004 Mar;52(3):158-60.
  50. Takayama H, Hamner CE, Caccitolo JA, Hisamochi K, Pearson PJ, Schaff HV. A novel antioxidant, EPC-K1, stimulates endothelial nitric oxide production and scavenges hydroxyl radicals. Circ J. 2003 Dec;67(12):1046-52.
  51. Kitamura T, Motomura N, Ohtsuka T, Shibata K, Takayama H, Kotsuka Y, Takamoto S. Aortopulmonary fistula in pseudoaneurysm after ascending aortic surgery. J Thorac Cardiovasc Surg. 2003 Sep;126(3):904-5.
  52. Suematsu Y, Takamoto S, Kaneko Y, Ohtsuka T, Takayama H, Kotsuka Y, Murakami A. Beating atrial septal defect closure monitored by epicardial real-time three-dimensional echocardiography without cardiopulmonary bypass. Circulation. 2003 107(5):785-90.
  53. Takayama H, Morota T, Motomura N, Ono M, Kotsuka Y, Takamoto S. Rupture of A Small Fusiform Thoracic Aortic Aneurysm. Jpn J Thorac Cardiovasc Surg. 2003 51: 32-33.
  54. Murakami A, Takamoto S, Takaoka T, Kobayashi J, Maeda K, Takayama H, Motomura N, Murakawa T, Ono M. Saphenous vein homograft containing a valve as a right ventricle-pulmonary artery conduit in the modified Norwood operation. J Thorac Cardiovasc Surg 2002 124: 1041-1042.
  55. Murakami A, Maeda K, Takayama H, Takaoka T, Kobayashi J, Takamoto S. Successful treatment with intraluminal fibrinogen injection of serous leakage from a polytetrafluoroethylene Blalock-Taussig shunt. J Thorac Cardiovasc Surg 2002 124: 1037-1038.
  56. Takayama H, Sekiguchi A, Chikada M, Noma M, Ishizawa A, Takamoto S. Mortality of Pulmonary Artery Banding in the Current Era. Ann Thorac Surg. 2002 74: 1219-24.
  57. Chikada M, Sekiguchi A, Takayama H, Tonari K, Saito A, and Ishizawa A. Usefulness of pulsatile bidirectional cavopulmonary shunt in high-risk fontan patients. Ann. Thorac. Surg. 2002 74: 971-2.
  58. Chikada M, Sekiguchi A, Oho S, Miyamoto T, Ishida R, Takayama H, Ishizawa A. Dilatable banding of a Blalock-Taussig shunt. Ann Thorac Surg. 2002;74:253-5.
  59. Takayama H, Sekiguchi A, Chikada M, Noma M, Ishida R. Aortopulmonary window due to balloon angioplasty after arterial switch operation. Ann Thorac Surg. 2002;73:659-61.
  60. Hirata Y, Ohtsuka T, Motomura N, Kubota H, Takayama H, Kitahori K, Kotsuka Y, Takamoto S. Three Cases of Coronary Artery Bypass Grafting with Vein Graft Anastomosed Proximally to the Axillary Artery and Placed through the Chest Cavity. Jpn Circ J; 65: 609.
  61. Takayama H, Sekiguchi A, Chikada M. 1995. Pulmonary atresia with intact ventricular septum: long-term results of "one and a half ventricular repair". Updated in 2001. Ann Thorac Surg. 2001;72:2178-9.
  62. Takayama H, Ohba N, Ori T, Takagi M, Nakagami K, Iseki J, Toyama K, Ito K, Muro H. Three Successfully resected cases of hepatocellular carcinoma with bile duct thrombi. Jpn J Gastroenterol Surg. 2000; 33: 1910-4.
  63. Ohba N, Tohyama K, Iseki J, Nakagami K, Takagi K, Ori T, Watanabe M, Sato Y, Takayama H, Hiramatsu Y, Ito K. Surgical Resection of An Epithelioid Hemangioendothelioma with Peritoneal Dissemination. Jpn J Gastroenterol Surg. 1999.

For a complete list of publications, please visit PubMed.gov