Mercedes Martinez, MD

Academic Appointments

  • Associate Professor of Pediatrics at CUMC

Current Administrative Positions

  • Medical Director, Intestinal Transplant Program, Center for Liver Disease and Abdominal Organ Transplantation
  • Clinical Director, Human Studies Core, Columbia Center for Translation Immunology
  • Associate Program Director, Liver Transplant Hepatology Fellowship
Mercedes Martinez, MD

Mercedes Martinez, MD, is an Associate Professor of Pediatrics and the Medical Director for the Intestinal Transplant Program at the Center for Liver Disease and Abdominal Organ Transplantation. She provides state-of-the-art care for children with a multitude of liver and intestinal issues, including children with liver and intestinal failure that require transplantation, children with intestinal failure, and for those with intestinal failure associated liver disease. Her research interests include liver tumors in children, autoimmune liver diseases, metabolic disorders, nutritional deficiencies associated with liver diseases, and intestinal failure.

  • liver tumors in children
  • autoimmune liver diseases
  • metabolic disorders
  • nutritional deficiencies associated with liver diseases
  • intestinal failure

Languages Spoken

  • Spanish

Education and Training

  • Higher Institute of Medical Sciences, Santiago De Cuba
  • Internship: Lincoln Medical and Mental Health Center Bronx, NY
  • Residency: Lincoln Medical and Mental Health Center Bronx, NY
  • Residency: Children's Hospital, Santiago De Cuba
  • Fellowship: NewYork-Presbyterian Hospital/Columbia University Medical Center

Lab Locations

  • CUMC/Presbyterian Hospital and Vanderbilt Clinic

    622 West 168th Street
    New York, NY 10032
    (212) 305-4343

NIH Grants


    Jun 25 2018 - May 31 2023


    Apr 3 2018 - Apr 3 2023


    Feb 8 2018 - Jan 31 2023


    Aug 1 2018 - Jul 31 2020


    Jul 1 2017 - Jun 30 2019


    Jun 1 2013 - May 31 2019


    Jun 1 2013 - May 31 2018


    Jul 27 2012 - Jun 30 2017


(Underline indicates mentees, *indicates senior authorship) 

Peer-Reviewed Articles

Perito ER, MartinezM,TurmelleY, Mason K, Spain KM, BucuvalasJC, FengS. Post-transplant Biopsy Risk among Stable Long-term Pediatric Liver Transplant Recipients: 451 Percutaneous Biopsies from Two Multi-center immunosuppression Withdrawal Trials. Accepted to AJT

Chuadhry S, Kato Y, Weiner J, Alonso-Guallart P, Baker S, Woodland DC III, Lefkowitch JH, Y Duran-Struuck R, Sondermeijer HP, Zitsman J, Sears M, Wu A, Karolewski B, Houck PJ, Martinez M, Kato T, Sykes K, Griesemer A. Transient mixed chimerism for the induction of tolerance in nonhuman primates: Comparison of results between liver and kidney transplants. Nature scientific reports

Vittorio J, Martinez M, Lobritto SJ. Partial splenic embolization is safe and effective alternative in the management of portal hypertension in Children. Accepted JPGN

FuJ, ZuberJ, Martinez M, ShontsB, ObradovicA, Wang H, Lau SP, Xia A, WaffarnEE, SavageTM, SimpsonMT, YangS, GuoX, MironM, SendaT, Rogers K, RahmanA, Ho SH, Shen Y, Griesemer A, FarberD, Kato T, Sykes M. Human intestinalAllografts Contain FunctionalHematopoietic Stem and Progenitor Cellsthat are Maintained by a Circulating Pool. Cell Stem Cell. 2018 Nov 21. PMID: 30503142

Deneau M, El-Matary W, Valentino P, Abdou R, Alqoaer K, Amin M, Amir A, Auth M, Bazerbachi F, Broderick A, Chan A, Cotter J, Doan S, El-Youssef M, Ferrari F, Furuya K, Gottrand F, Gottrand M, Gupta N, Homan M, Kamath B, Kim KM, Kolho K, Konidari A, Koot B, Iorio R, Ledder O, Mack C, Martinez M,Miloh T, Mohan P, OCathain N, Papadopoulou A, Ricciuto A, Saubermann L, Sathya P, Shteyer E, Smolka V, Tanaka A, Varier R, Venkat V, Vitola B, Vos M, Woynarowski M, Yap J, Jensen MK. GGT improvement predict survival in pediatric primary sclerosing cholangitis regardless of ursodeoxycholic acid use. Hepatology Communications. 2018 Sep 25. PMID: 30411083

Goldner D,Vittorio J, Barrios DM, McGuire J, Brodlie S,Brown J, Lobritto S, *Martinez M. BoneFractures in Children with Cholestatic Liver Disease May Mimic those seen in Child Abuse. Accepted Pediatric Emergency Care.

Arterbery A, Yao J, Ling A, Avitzur Y, Martinez M,Lobritto S, Deng Y, Geliang G, Mehta S, Wang G, Knight J, PhD5, Ekong UD. Inflammasome priming mediated via toll-like receptors 2 and 4 indices TH1-like Treg in the DeNovo autoimmune hepatitis. Frontiers in immunology. 2018 Jul 19;PMID: 30072988 PMCID: PMC6060440

Ravella S, Liou P, Velassco M, Harrison A, Kato T, *MartinezM. Nutritional challenges in patients after intestinal auto-transplantation and ex-vivo surgery. JPEN. 2018 Jul 20. PMID: 30028516

Elnaggar A, Griesemer A., Bentley-Hibbert S, Brown RS Jr., Lobritto S, Martinez M, Kato T, Emond J.Liver Atrophy and Regeneration in Non-Cirrhotic Portal Vein Thrombosis: Effect of Surgical Shunts. Liver Transpl.2018 Jan 29. PMID: 29377486

Chaudhry S, Bentley-Hibbert S, Stern J, Lobritto S, Martinez M, Vitorrio J, Halazun KJ, Lee HT, Emond J, Kato T, Samstein B, Griesemer A. Growth of Liver Allografts Over Time in Pediatric Transplant Recipients. Pediatr Transplant. 2018 Jan 15. doi: 10.1111/petr.13104. PMID: 29334158

Przybyzsewski E, Verna E, Lobritto S, Martinez M, Vittorio J, Fox AN, Samstein B, Kato T, Griesemer A, Emond J. Durable Clinical and Immunologic Advantage of Living Donor Liver Transplantation in Children. Transplantation.2018 Jan 23. PMID: 29369249

Kato Y, MD, Griesemer AD, Wu A, Sondermeijer H, Weiner J, Duran-Struuck R, Martinez M, Slate A, Romanov A, Lefkowitch JH, Sykes M, Kato T. Novel H-shunt Veno-venous Bypass for Liver Transplantation in Cynomolgus Macaques. Comparative Medicine. 2017 Oct 1; 67, (5). PMID: 28935006

Ekong UD, McKiernan P, Martinez M, Lobritto S, Kelly D, Ng VL, Alonso EM, Avitzur Y. Long-Term Outcomes of De Novo Autoimmune Hepatitis in Pediatric Liver Transplant Recipients. Pediatric Transplantation. 2017 May 29. doi: 10.1111/petr.12945. PMID: 28556542

Deneau M, El-Matary W, Valentino P, Abdou R, Alqoaer K, Amin M, Amir A, Auth M, Bazerbachi F, Broderick A, Chan A, Cotter J, Doan S, El-Youssef M, Ferrari F, Furuya K, Gottrand F, Gottrand M, Gupta N, Homan M, Kamath B, Kim KM, Kolho K, Konidari A, Koot B, Iorio R, Ledder O, Mack C, Martinez M,Miloh T, Mohan P, OCathain N, Papadopoulou A, Ricciuto A, Saubermann L, Sathya P, Shteyer E, Smolka V, Tanaka A, Varier R, Venkat V, Vitola B, Vos M, Woynarowski M, Yap J, Jensen MK. The natural history of primary sclerosing cholangitis in 781 children: an international, multicenter collaboration. Hepatology. 2017 April 8. PMID: 28390159

Weiner J, Zuber J, Shonts B, Yang S, Fu J, Martinez M, FarberD, Kato T, Sykes M. Long-term persistence of innate lymphoid cells in the gut after intestinal transplantation. Transplantation. 2016. Dec 8. PMID: 27941430 PMCID: PMC5462871

Duran-Struuck R, Sondermeijer HP, Bühler L, Zitsman J, Kato Y, Wu A, Alonso-Guallart P, McMurchy A, Woodland D, Griesemer A, Martinez M, Boskovic S, Kawai T, Cosimi AB, Wuu AA, Slate A, Baker S, Tokarz R, d'Agati V, Hammer S, Pereira M, Lipkin I, Wekerle T, Levings M, Sykes K. Effect of ex-vivo expanded recipient regulatory T-cells on hematopoietic chimerism and kidney allograft tolerance across MHC barriers in Cynomolgus macaques. Transplantation 2017. Feb. 01(2):274-283. PMID: 27846155. PMCID: PMC5263090

Zuber J, Shonts B, Lau SP, ObradovicA, Fu J,Yang S, LambertM, Coley S, Weiner J, Thome J, DeWolf S,FarberD, Shen Y, Caillat-ZucmanS, Bhagat G, Griesemer A, Martinez M, Kato T, Sykes M. Bidirectional intragraft alloreactivity drives the repopulation of human intestinal allografts and correlates with clinical outcome. Sci Immunol.2016 Oct;1(4). pii: eaah3732.doi:10.1126/sciimmunol.aah3732. Epub 2016 Oct 7. PMID: 28239678 PMCID: PMC5323244

Geller J, Kasahara M, Martinez M, Soresina A, Endrikat J. Safety and efficacy of of Gadoxetate disodium Enhanced Liver MRI in Pediatric Patients aged ˃2 Months to

Martinez M, Brodlie S, Griesemer A, Kato T, Harren H, Gordon B, Parker T, Levine D, Tyberg T, Starc T, Cho I, Min J, Elmore K, Lobritto S, Hudgins LC. Effects of Liver Transplantation on Lipids and Cardiovascular Disease in Children With Homozygous Familial Hypercholesterolemia. Am J Cardiol. 2016 Aug 15;118(4):504-10. doi: 10.1016/j.amjcard.2016.05.042 PMID: 27365335

Sung D, Luga AC, Kato T, MartinezM, Remotti HE, Lagana SM. Crypt Apoptotic Body Counts in Normal Ileal Biopsies Overlap with Graft Versus Host Disease and Acute Cellular Rejection of Small Bowel Allografts. Human Pathology 2016 Oct;56:89-92. doi: 10.1016/j.humpath.2016.05.017. PMID: 27246175

Arterbery AS, Osafo-Addo A, Avitzur Y, Ciarleglio M, Deng Y, Lobritto SJ, Martinez M, Hafler DA, Kleinewietfeld M, Ekong UD. Production of Proinflammatory Cytokines byMonocytes in Liver-Transplanted Recipients with De Novo Autoimmune Hepatitis Is Enhanced and Induces TH1-like Regulatory T Cells. Journal of Immunology 2016 May 15;196(10):4040-51. doi: 10.4049/jimmunol.1502276. Epub 2016 Apr 18. PMID: 27183637PMCID: PMC4874532

Weiner J, Griesemer A, Island E, Lobritto S, Martinez M, Selvaggi G, Lefkowitch J, Velasco M, Tryphonopoulos P, Emond J, Tzakis A, Kato T. Long-Term Outcomes of Auxiliary Partial Orthotopic Liver Transplantation in Pre-Adolescent Children with Fulminant Hepatic Failure. Liver Transplantation. 2016 Apr;22(4):485-94. PMID: 26479577

Ayyala R, Martinez M, Lobritto S, Kato T, Ruzal-Shapiro C. Postoperative imaging findings in children with auxiliary partial orthotopic liver transplant (APOLT).Pediatric Radiology. 2016 Feb 11. PMID: 26867605

Zuber J, Rosen S, Shonts B, Sprangers B, Richman S, Yang S, LauSP, DeWolfS, Vlad G, Zorn E, Wong W, Emond J, Martinez M, Kato T, Sykes M.Macrochimerism in intestinal transplantation: association with lower rejection rates and multivisceral transplants, without GVHD. American Journal of Transplantation. 2015 Oct;15(10):2691-703. PMID: 25988811. PMCID: PMC4575629

Oh PS, Fingeret AL, Shah MY, Ventura KA, Brodlie S, Ovchinsky N, Martinez M, LobrittoSJ, Cowles RA. Improved tolerance for enteral nutrition after serial transverse enteroplasty (STEP) in infants and children with short bowel syndrome-A seven-year single-center experience. Pediatr Surg. 2014 Nov; 49(11): 1589-92. PMID: 25475799

Pierog A, Martinez M, Mencin A. Outpatient Endoscopic Closure of Persistent Gastrocutaneous Fistula with Hemoclips in Pediatrics. Gastrointestinal Endoscopy. 2014 Sep; S0016-5107 (14) 02039-2. PMID: 25281501

Radhakrishnan K, Bishop J, Jin Z, Kothari K, Bhatia M, George D, Garvin JH Jr, Martinez M,Ovchinsky N, Lobritto S, Elsayed Y, Satwani P. Risk factors associated with liver injury and impact of liver injury on transplantation related mortality in pediatric recipients of allogeneic hematopoietic stem cell transplantation. Biology Blood Marrow Transplant. 2013 Jun; 19(6): 912-7. PMID: 23467127

Remotti H, Subramanian S, Martinez M,Kato T, Magid MS. Small-bowel allograft biopsies in the management of small intestinal and multivisceral transplant recipients: histopathologic review and clinical correlations. Arch Pathol Lab Med.2012 Jul; 136(7): 761-71. PMID: 22742549

Kato T, Lobritto S. J., Tzakis A, Raveh Y, Sandoval P. R., Martinez M, Granowetter L, Armas A, Brown, R. S. Jr., Emond J. Multivisceral Ex Vivo Surgery for Tumors Involving Celiac and Superior Mesenteric Arteries. American Journal of Transplantation. 2012 May; 12(5): 1323-8. PMID: 22300017

Cowles RA, Ventura KA, Martinez M, Lobritto SJ, Harren PA, Brodlie S, Carroll J, Jan DM. Reversal of intestinal failure-associated liver disease in infants and children on parenteral nutrition: experience with 93 patients at a referral center for intestinal rehabilitation. Pediatric Surg. 2010 Jan; 45(1): 84-7; discussion 87-8.PMID: 20105585

Case Reports

Paul EA, Chelliah A, Torres A, Martinez M, Ferris AM, Kalfa DM. Extra-anatomic suprahepatic to innominate vein conduit in heterotaxy. Journal of Thoracic and Cardiovascular Surgery. 2018 Mar 16. PMID: 29655540

Quillin RCIII, Bongu A, Kasper V, Vittorio JM, Martinez M, Lobritto SJ, Griesemer AD, Guarrera JV. Roux-en-Y Enterolith leading to Obstruction and Ischemic Necrosis after Pediatric Orthotopic Liver Transplantation. Pediatric Transplantation. 2018 Apr. DOI: 10.1111/pert.13160 PMID: 29607581

Kadakia N,Lobritto S, Ovchinsky N, Remotti H, Yamashiro DJ, Emond J, *Martinez M. A Challenging Case of Hepatoblastoma Concomitant with Autosomal Recessive Polycystic Kidney Disease and Caroli Syndrome-Review of the Literature. Front Pediatr. 2017. 2017 Jun 7;5:114. doi: 10.3389/fped.2017.00114. eCollection 2017. PMID: 28638817 PMCID: PMC5461266

Picoraro J, Ovchinsky N, Martinez M,Lobritto S, Satwani P, Kato T. First Attempt of Sequential Living Donor Liver and Hematopoietic Stem Cell Transplantation in a Child with Advanced Hepatocellular Carcinoma: A Case Report. Transplant Proc. 2016 Nov; 48(9); 3174-3177. PMID: 27932175

Taylor S, Vittorio J, Martinez M,Fester K, Lagana S, Lobritto S, OvchinskyN. Anakinra-induced acute liver failure in an adolescent patient with Still's disease. Pharmacotherapy. 2016 Jan 9. PMID: 26749403

Taylor S, Lobritto S, Orellana K, Novak I, Jan D, Martinez M, OvchinskyN. Pyogenic Liver Abscess Masquerading as a Hepatic Neoplasm. J Pediatr Gastroenterol Nutr.2015 Jul; 61 (1). PMID: 24345844

Weiner J, Wu J, Martinez M, Lobritto S, OvchinskyN, Rohde C, Griesemer A, Kato T. The use of bi-planar tissue expanders to augment abdominal domain in a pediatric intestinal transplant recipient. Pediatric Transplantation 2014 Aug; 18(5): E174-9. PMID: 25041331. PMCID: PMC4367952

Invited Reviews/Chapters

Martinez M, Kato T. Cuidado posoperatorio del paciente pediátrico después de trasplante hepático. Trasplantes. Fondo Editorial Comunicacional. R.E.P. Lima Peru. 2017.

Martinez M, Lobritto S, Emond J "Chapter 72: Postoperative Care of Pediatric Transplant Recipients.Transplantation of the Liver. Ed.Busuttil andKlintmalm3 edition Elsevier Saunders, 2015.

For a complete list of publications, please visit